Breast cancer: Oncogenes and suppressor genes
نویسندگان
چکیده
منابع مشابه
Oncogenes and tumor suppressor genes.
The genetic paradigm of cancer — that tumors arise as a consequence of the accumulation of mutations in genes controlling cell proliferation, differentiation or death — is now widely accepted. The purpose of this is lecture provide a review of current knowledge on the various types of cancer genes identified so far in different stages of tumor development. We will also address recent attempts t...
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Breast cancer progression involves multiple genetic events, which can activate dominant-acting oncogenes and disrupt the function of specific tumor suppressor genes. This article describes several key oncogene and tumor suppressor signaling networks that have been implicated in breast cancer progression. Among the tumor suppressors, the article emphasizes BRCA1/2 and p53 tumor suppressors. In a...
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Prognosis in lung cancer, one of the commonest cancers in the developed world, is poor, with less than 13% of all lung cancer patients surviving more than 5 years after diagnosis. With such an elevated mortality rate, it is important to elucidate the genetic changes involved in the pathogenesis of lung cancer. The process of carcinogenesis can be divided into the three stages of initiation, pro...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 1990
ISSN: 0923-7534
DOI: 10.1093/oxfordjournals.annonc.a057739